Fri Nov 17 2023

28 articles - From Friday Nov 10 2023 to Friday Nov 17 2023

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

J Crohns Colitis

Anti-tumor necrosis factor alpha versus corticosteroids: a threefold difference in the occurence of venous thromboembolism in Inflammatory Bowel Disease - a systematic review and meta-analysis.

Biologics should be preferred over corticosteroids in cases of severe flare-ups and multiple VTE risk factors, as they are associated with reduced odds of these complications. Further studies are needed to validate our data.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Adherence to the Mediterranean diet and Nuclear Magnetic Resonance Spectroscopy Biomarkers in Older Individuals at High Cardiovascular Risk: Cross-sectional and Longitudinal Analyses.

In older adults at high cardiometabolic risk, higher MEDAS was associated with modest beneficial changes in lipoprotein and glucose metabolism. The results suggest that lipoprotein subclass distribution and glycemic control are potential mechanisms behind the well-known salutary effects of MedDiet on CVD and diabetes risk. Future clinical trials exploring the effects of the MedDiet on advanced lipoprotein subclass profiles and glucose metabolism markers are needed to confirm the results of our study.

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Effectiveness of Intermittent Iron and High-Dose Vitamin A Supplementation on Cognitive Development of Schoolchildren in Southern Ethiopia: A Randomized Placebo Controlled Trial.

In a population where the prevalence of iron deficiency is low, intermittent iron supplementation did not have any or negative effect on the child's cognitive development outcomes. Whereas VA supplementation improved the child's working memory.

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Infant Milk Formula with Large, Milk Phospholipid-coated Lipid Droplets Enriched in Dairy Lipids Affects Body Mass Index Trajectories and Blood Pressure at School Age: Follow-up of a Randomized Controlled Trial.

Early life feeding of an innovative IMF with large, milk phospholipid-coated lipid droplets enriched with dairy lipids results in a BMI trajectory closer to breastfed infants and a lower blood pressure at school age.

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Sex Disparities in Parenteral and Enteral Nutrition Society Leadership Worldwide: A 20-Year Retrospective Analysis.

Over the last two decades, women have been consistently underrepresented in prominent leadership roles in parenteral and enteral nutrition societies globally. Although there has been a noticeable shift towards more women in chair positions, true sex equality remains elusive. Moreover, sex disparities are even more pronounced in positions such as conference presidents, authors of major guidelines, and editors-in-chief of society-affiliated journals. This data underscores the pressing need to enhance efforts towards sex equality across these domains.

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Inflamm Bowel Dis

Adalimumab Drug Levels at Secondary Loss of Response Do Not Predict Response to Dose-intensification in Crohn's Disease: A Retrospective, International Multicenter Study.

Drug levels following dose-intensification rather than at the time of secondary loss of response were associated with subsequent CD remission.

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Exclusive Enteral Nutrition Mediates Beneficial Gut Microbiome Enrichment in Acute Severe Colitis.

Augmentation of clinical response by EEN-conjugated corticosteroid therapy is accompanied by beneficial gut microbial changes in patients with ASUC.

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Incidental Dysplasia During Total Proctocolectomy With Ileoanal Pouch: Is It Associated With Worse Outcomes?

Pouch survival at 10 years was 96% for PRE, 99% for BOTH, and 97% for POST (P = .24). The incidental finding of dysplasia on final pathology after proctocolectomy was not associated with worsened outcomes compared with preoperatively diagnosed dysplasia.

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Inflammatory Bowel Disease and the Risk of Anal Squamous Intraepithelial Lesions and Anal Cancer in Men Who Have Sex With Men.

Among MSM with and without IBD, both groups had an equally high prevalence of HSIL and anal SCC. Awareness of appropriate surveillance to identify aSIL in MSM patients with IBD is needed among gastroenterologists.

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Single Nucleotide Polymorphisms of the MEFV Gene E148Q Are Highly Associated With Disease Phenotype in Crohn's Disease.

MEFV gene SNPs, including E148Q, modify the behavior of CD. IL-1ß and IL-18 are produced through enhanced caspase-1 activity in monocytes of CD patients with E148Q. IL-1ß promotes gene expression of fibrosis-related genes by cooperating with IL-17A in myofibroblasts. Therefore, E148Q might be a disease-modifying gene associated with the fibrostenosis phenotype in CD patients.

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J Crohns Colitis

De-escalation of biological treatment in inflammatory bowel disease: A comprehensive review.

Any consideration for de-escalation of biological therapy in IBD must be tailored, taking into account the risks and consequences of a flare and patients' preferences.

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Impact of Baseline Corticosteroid Use on the Efficacy and Safety of Upadacitinib in Patients with Ulcerative Colitis: a Post Hoc Analysis of the Phase 3 Clinical Trial Programme.

Upadacitinib is an effective steroid-sparing treatment in patients with moderately to severely active ulcerative colitis.

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The Safety, Tolerability, Pharmacokinetics and Clinical Efficacy of the NLRX1 agonist NX-13 in Active Ulcerative Colitis: Results of a Phase 1b Study.

NX-13 was generally safe and well tolerated with early signs of rapid symptom and endoscopic improvement. This novel mechanism of action warrants further investigation. ClinicalTrials.gov NCT04862741.

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Treatment of antibiotic refractory chronic pouchitis with JAK inhibitors and S1P receptor modulators: an ECCO CONFER Multicentre Case Series.

No side effects reported. Small molecules may represent a suitable option for CARP refractory to multiple biologics, deserving further investigation.

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Pancreas

Hypophosphatemia as a Predictor of Clinical Outcomes in Acute Pancreatitis: A Retrospective Study.

Early hypophosphatemia during an admission for AP was associated with increased AP severity, ICU admission, and longer length of stay.

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The Impact of Race on Pancreatic Cancer Treatment and Survival in the Nationwide Veterans Affairs Healthcare System.

Equal access to healthcare might have reduced but failed to eliminate disparities. Dedicated efforts are needed to understand reasons underlying these disparities in an attempt to close these persistent gaps.

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Pancreatology

A journey to and with the stars: The pancreatic stellate cell story.

This paper summarises her Palade lecture wherein she reflects on her journey as a medical graduate, an academic and a researcher, with a particular focus on her team's pioneering work on pancreatic stellate cell biology and the role of these cells in health and disease. While there has been much progress in this field with the efforts of researchers worldwide, there is much still to be learned; thus it is a topic with ample scope for innovative research with the potential to translate into better outcomes for patients with pancreatic disease.

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Clinical characteristics of three distinct types of pancreatitis with overlapping etiologies: A ten-year retrospective cohort study.

ABP usually develops in people aged 50-59 years. HTG-AP primarily affects people aged 30-39 years. However, the peak incidence age of BHAP falls between the two aforementioned age groups (40-49 years). We also found that patients with BHAP seem to be in an intermediate state in terms of some biochemical markers and demographic characteristics. Furthermore, BHAP may have the worst clinical outcomes compared with HTG-AP and ABP.

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Cysts or necrotic components in pancreatic ductal adenocarcinoma is associated with the risk of EUS-FNA/B complications including needle tract seeding.

We should pay attention to the risks of EUS-FNA/B complications, including NTS, when the tumor has cysts or necrotic components.

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Genetic and functional analysis of chymotrypsin-like protease (CTRL) in chronic pancreatitis.

We identified several CTRL variants, some showing potent effects on protease function and secretion. We observed these effects in variants found in patients and controls, and CTRL loss-of-function variants were not significantly more common in patients than controls. Therefore, CTRL is unlikely to play a relevant role in the development of CP.

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Increased plasma miR-370-3p expression in poor-outcome patients with pancreatic ductal adenocarcinoma.

Plasma miR-370-3p expression upregulation correlates with poor prognosis in patients with PDAC.

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Overexpression of the adhesion signaling pathway is linked to short-term survival in pancreatic ductal adenocarcinoma.

The role of integrins in the tumor microenvironment of pancreatic cancer is of utmost importance, as they are found to be overexpressed in short-term survivors. These findings provide valuable insights into the underlying biology of PDAC and have potential implications for the development of therapeutic strategies.

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Pancreas volumes in pediatric patients following index acute pancreatitis and acute recurrent pancreatitis.

A significant fraction (40 %) of children with ARP have pancreas volumes <5th percentile for BSA even in the absence of CP. A similar, but not statistically significant, fraction have pancreas volumes <25th percentile after an index attack of AP. Pancreatic parenchymal volume deserves additional investigation as an objective marker of parenchymal damage from acute pancreatitis and of progressive pancreatitis in children.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link


Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Inflamm Bowel Dis

Cancer Screening in Patients With Inflammatory Bowel Disease: Don't Forget the Anus!

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J Crohns Colitis

Kidney injuries as Extra Intestinal Manifestation of Inflammatory Bowel Disease.

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Pancreas

Immune Enhancement in Patients With Predicted Severe Acute Necrotizing Pancreatitis: Important Implications for Timing and Early Stratification.

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Response to Letter to the Editor "Design Flaws in Study of Prophylaxis of Postendoscopic Retrograde Cholangiopancreatography Pancreatitis" by Feng Liu et al.

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Widespread Hyperalgesia by Pancreatic Quantitative Sensory Testing Is Associated With Reduced Pain Response in Chronic Pancreatitis.

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Letters&Replies

Letters to the editors and authors’ replies